anti-oestrogen

anti-oestrogen
= oestrogen-receptor antagonist; n.
one of a group of drugs that oppose the action of oestrogen by binding to oestrogen receptors in the body's tissues. The most important of these drugs is currently tamoxifen, which is used in the treatment of breast cancers dependent on oestrogen. Because they stimulate the production of pituitary gonadotrophins, some anti-oestrogens (e.g. clomifene, tamoxifen) are used to induce or stimulate ovulation in anti-infertility treatment. Side-effects of anti-oestrogens include hot flushes, itching of the vulva, nausea, vomiting, fluid retention, and sometimes vaginal bleeding.

The new mediacal dictionary. 2014.

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  • anti-oestrogen — n. one of a group of drugs that oppose the action of oestrogen. The most important of these drugs is currently tamoxifen, which antagonizes the action of oestrogens at the tissue receptors and is used in the treatment of breast cancers dependent… …   Medical dictionary

  • oestrogen receptor — a specific site on the surface of a cell that binds to oestrogen; the binding triggers responses of the cell to the hormone (see receptor). Oestrogen receptors occur on all target cells normally responsive to oestrogen (e.g. in the uterus) and… …   The new mediacal dictionary

  • oestrogen receptor — a specific site on the surface of a cell that binds to oestrogen; the binding triggers responses of the cell to the hormone. anti oestrogen, used for treating breast cancer, act by preventing the binding of oestrogen to these receptor …   Medical dictionary

  • oestrogen-receptor antagonist — see anti oestrogen …   The new mediacal dictionary

  • Tamoxifen — Systematic (IUPAC) name (Z …   Wikipedia

  • selective (o)estrogen receptor modulator — SERM a drug that has oestrogen like activity in some tissues and an anti oestrogenic effect in others, depending on the manner of its binding with the oestrogen receptors. Tamoxifen was the first SERM to be introduced. Because of its activity as… …   The new mediacal dictionary

  • selective (o)estrogen receptor modulator — SERM a drug that has oestrogen like activity in some tissues and an anti oestrogenic effect in others, depending on the manner of its binding with the oestrogen receptors. Tamoxifen was the first SERM to be introduced. Because of its activity as… …   The new mediacal dictionary

  • tamoxifen — n. a drug used in the treatment of breast cancer: it binds with hormone receptors in the tumour to inhibit the effect of oestrogens (see anti oestrogen, selective oestrogen receptor modulator). Tamoxifen is also used to treat female infertility… …   The new mediacal dictionary

  • Tenovus — is a British cancer charity committed to the control of cancer through: quality research, prevention/education, counselling and patient care. The Charity Tenovus was established in Cardiff in 1943 by ten businessmen (hence the ten of us ), the… …   Wikipedia

  • tamoxifen — Synthetic anti oestrogen used in chemotherapy of breast carcinoma. Probably has other effects, including inhibition of chloride channel conductance …   Dictionary of molecular biology

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